Bead beating can be quite effective if done correctly, though traditionally it was a bottleneck due to the limited number of samples that could be processed. To remedy this limitation, several companies developed bead beaters (formerly called mixer mills) that could handle racks of tubes or even microwell plates.

Though simple in theory, bead beating can be quite complex as several factors must work together to effectively homogenize samples:

  • The tube, or microwell plate, used in bead beating is not just a sample holder, but actively participates in the homogenization. 
  • The stroke length of the amalgamator or mixer mill is also critical, as is the physical motion it imparts on the sample tube. 
  • Finally, sample type, mass, volume, and extraction buffer all impact the effectiveness of the homogenization

In choosing a bead beater, the number of samples processed simultaneously should be taken into consideration, especially for laboratories processing hundreds of samples daily.

Homogenizer Comparison
  HT Mini™ HT 6™  HT 24™ HT Homogenizer II 1600 MiniG™ 2010 GenoGrinder®
Low Speed/High Speed 2700/4000 rpm 2500/4250 rpm 2500/4250 rpm 300/1600 rpm 500/1500 strokes/minute  500/1750 strokes/minute
Motion Arc Arc Figure 8 Linear
Cryogenic Capabilities  No Yes
Ideal Sample types Most samples, aside from elastic, hard animal tissue, and bark or seeds. All Sample types
Disruption Tubes 3 (non-skirted) 6 24 24 50 100
4 ml Vials - - - 24 48 96
15 ml Vials - - - 5 10 20
50 ml Vials  - - - - 5 10
Deep 96 Well Plate - - -   2 4-6


For more information on the homogenizer's capabilities refer to our Bead Beating Guide's section on Bead Beaters

1600 MiniG®

At just over half the cost of a 2010 GenoGrinder, the 1600 Mini G is a great alternative homogenizer for labs that process many samples.

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Geno/Grinder® 2010, 115V

The Geno/Grinder® 2010 is a high throughput homogenizer for the most demanding labs.

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HT 24™
HT 24™

A tabletop bead beater that processes samples in microfuge tubes.

Additional Info
HT 6™
HT 6™


HT Mini™
HT Mini™

 The HT Mini provides an efficient means to bead beating but at a fraction of the cost.