Low Binding Beads are chemically treated so they bind less solutes liberated from homogenized samples. Untreated Silica and Zirconium Beads (Zirconium Silicate) have surface chemistries that bind DNA, RNA, and proteins upon disruption of cells. Both enzyme and PCR-based assays have lower sensitivity when analytes are liberated using untreated beads. Low Binding Beads yield a greater concentration of solutes and provide greater range and linearity, especially in real-time PCR assays.
Also available in pre-filled tubes!